The comedy series A.P. Bio has captured viewers’ hearts with its unique premise, clever writing, and hilariously talented ensemble cast. The series revolves around the antics of a disgraced Harvard philosophy professor who takes up a teaching position at a high school and decides to use his students as pawns in his vendettas. However, the authentic charm of the show lies in the dynamic performances of the AP Bio cast, each bringing their quirks and hilarity to the screen. Let’s dive into the main and supporting cast that makes this show a must-watch.
Main Cast of A.P. Bio
Glenn Howerton as Jack Griffin
Jack Griffin is the sarcastic and self-centered protagonist of A.P. Bio. Played brilliantly by Glenn Howerton, Jack is a former Harvard philosophy professor who begrudgingly accepts a job teaching advanced placement biology at Whitlock High School. Far from being the ideal educator, Jack is more interested in exacting revenge on those he believes have wronged him than in teaching biology. His sharp wit, manipulative schemes, and undeniable charisma make him frustrating and entertaining. Howerton’s performance captures the complexity of a flawed and oddly likable character.

Patton Oswalt as Principal Ralph Durbin
Patton Oswalt delivers a comedic masterpiece as Principal Ralph Durbin, the childlike and often clueless principal of Whitlock High School. Durbin’s good intentions are usually overshadowed by his naivety and eagerness to please. Despite his shortcomings, he genuinely cares about his students and staff, making him one of the most endearing characters in the show. Oswalt’s comedic timing and ability to balance absurdity with sincerity make Durbin a fan favorite.
Lyric Lewis as Stef Duncan
Lyric Lewis plays Stef Duncan, a history teacher at Whitlock High School and one of Jack’s closest confidants. Stef often reluctantly gets roped into Jack’s schemes, though her pragmatic nature and sense of humor balance their dynamic. Her sharp observations and unfiltered commentary make her one of the standout characters in the AP Bio cast.
Mary Sohn as Mary Wagner
Mary Wagner, portrayed by Mary Sohn, is the art teacher at Whitlock High and another of Jack’s inner circle. With her quick wit and playful teasing, she provides a lighthearted dynamic to the group of teachers. Mary’s interactions with Principal Durbin and her humorous take on situations make her a delightful addition to the cast.
Jean Villepique as Michelle Jones
Jean Villepique plays Michelle Jones, the health and home economics teacher who is often the voice of reason among her friends. Her calm demeanor and occasional exasperation with Jack’s antics provide a grounding presence amidst the chaos. Villepique’s nuanced performance adds depth to Michelle’s character, making her an essential part of the AP Bio cast.
Supporting Cast
The supporting cast of A.P. Bio brings even more hilarity and charm to the show. These characters, while secondary, play pivotal roles in creating the comedic magic of the series.
Aparna Brielle as Sarika Sarkar
Aparna Brielle portrays Sarika Sarkar, an overachieving student who often finds herself at odds with Jack. Her determination and moral compass make her a foil to Jack’s chaotic schemes.
Nick Peine as Marcus Kasperak
Nick Peine plays Marcus Kasperak, Jack’s self-proclaimed “least favorite student.” Marcus frequently becomes the target of Jack’s pranks, adding an extra layer of humor to the classroom dynamics.
Allisyn Snyder as Heather Wilmore
Allisyn Snyder plays Heather Wilmore, a soft-spoken and seemingly timid student who surprisingly becomes one of Jack’s most loyal underlings.
Eddie Leavy as Anthony Lewis
Eddie Leavy portrays Anthony Lewis, a sassy and outspoken student who often steals the spotlight with witty remarks.
Jacob Houston as Victor Kozlowski
Jacob Houston plays Victor Kozlowski, an awkward, slow-talking student whose quirky personality adds to the show’s charm.
Spence Moore II as Dan Decker
Spence Moore II plays Dan Decker, a reformed bully forced to join Jack’s class. His character adds a layer of unpredictability to the student group.
Other Notable Characters
The AP Bio cast wouldn’t be complete without mentioning a few other notable characters who add their unique flavor to the show:
- Paula Pell as Helen Demarcus: Principal Durbin’s eccentric secretary, whose quirks and comedic one-liners make her a scene-stealer.
- As Miles Leonard, Jack’s acadeJack’sval and the man who stole his dream job, Tom Bennett played with the perfect mix of smugness and charm.
- Charlie McCrackin as Coach Dick Novak: The gym teacher and football coach who brings his brand of humor to the halls of Whitlock High School.
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Why the AP Bio Cast Stands Out
The success of A.P. Bio lies in its exceptional cast. Each actor brings unique energy to their character, creating a rich tapestry of personalities that keep viewers engaged. The chemistry between the primary and supporting cast members elevates the show, making every scene feel dynamic and authentic.
From Glenn Howerton’s sharp-tongued performance as Jack Griffin to Patton Oswalt’s lovable portrayal of Principal Durbin, the AP Bio cast delivers a masterclass in comedy. Whether it’s the hilarious banter between teachers or the unpredictable antics of the students, this ensemble proves why A.P. Bio is a standout in the world of television comedies.
In conclusion, the AP Bio cast is a perfect blend of talent, humor, and heart. Their performances breathe life into the quirky world of Whitlock High School, making it a show that fans will continue to cherish. If you haven’t already, it’s time to dive into this hilarious series and experience the magic of the AP Bio cast!